Departments of Kinesiology and Public Health

Education

• Post-doctoral research fellowship - University of Missouri, Columbia

• Ph.D. in Bioenergetics - East Carolina University

• M.A. in Physical Education - California State University, Chico

• B.S. in Exercise Physiology - California State University, Chico

Current Teaching

• ES 2035 - Introduction to Human Anatomy & Physiology
• ES 3002 - Exercise Physiology
• ES 3003 - Exercise Physiology Laboratory
• ES 5624 - Physiology of Exercise

Professional Affiliations / Organizations

• American Physiological Society
• American College of Sports Medicine

Laboratory Affiliation

• Biochemistry (Director)
• Vivarium

Research Interests

• My primary scholarly interests include investigating the mechanisms responsible for sarcopenia (the age-related loss of skeletal muscle mass and strength) and skeletal muscle repair/regeneration after injury. My laboratory seeks to develop exercise and/or nutritional interventions for the treatment/prevention of sarcopenia and enhanced recovery of skeletal muscle from damage.
• Furthermore, my laboratory focuses on the role inflammation plays in sarcopenia and the failed regrowth from atrophy in aged skeletal muscle, as well as in skeletal muscle repair and regeneration after injury.
• Additionally, my laboratory investigates the role of exercise on the composition and diversity of the gut microbiome.

Current research projects include:

• Phytoecdysteroid supplementation on growth and function characteristics in young and old skeletal muscle in response to resistance and endurance exercise
• Phytoecdysteroid supplementation on the recovery of function and structural characteristics in young and old skeletal muscle in response to eccentric contraction-induced injury
• Influence of exercise on the composition, diversity, and function of the gut microbiota in young and aging subjects
• Effect of exercise on the recolonization and function of the gut microbiota after a course of antibiotics

Selected Publications

Google Scholar link for all publications

^# - denotes student trainee

• Zwetsloot, K.A., L.M. Westerkamp, B.F. Holmes, and T. P. Gavin. “AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise.” Journal of Physiology. 586(24). 6021-6035. 2008. doi: 10.1113/jphysiol.2008.159871
• Zwetsloot, K.A.*, A. Nedergaard*, T.E. Childs, and F.W. Booth. “Differences in transcriptional patterns of extracellular matrix, inflammatory, and myogenic regulatory genes in myofibroblasts, fibroblasts, and muscle precursor cells isolated from old male rat skeletal muscle using a novel cell isolation procedure.” Biogerontology. 13(4). 383-398. 2012. * - denotes authors contributed equally to this work. doi: 10.1007/s10522-012-9382-7
• Zwetsloot, K.A., T.E. Childs, L.T. Gilpin, and F.W. Booth. “Zero-passaged muscle precursor cells from old skeletal muscle have delayed proliferation and differentiation.” Cell Proliferation. 46(1). 45-57. 2013. doi: 10.1111/cpr.12007
• Zwetsloot, K.A., C.S. John^#, M.M. Lawrence^#, R.A. Battista, and R.A. Shanely. “High intensity interval training induces a modest inflammatory response in young active men.” Journal of Inflammation Research. 7. 9-17. 2014. doi: 10.2147/JIR.S54721
• Shanely, R.A., K.A. Zwetsloot, N.T. Triplett, M.P. Meaney, G.E. Farris, and D.C. Nieman. “Human skeletal muscle biopsy procedures using the modified Bergström technique.” Journal of Visualized Experiments. (91) e51812. 2014.  doi:10.3791/51812
• Zwetsloot, K.A., R.A. Shanely, E.K. Merritt, and J.M. McBride. Invited Review: “Phytoecdysteroids: A Novel, Non-Androgenic Alternative for Muscle Health and Performance.”  Journal of Steroids & Hormonal Science. 12:e001. 2014. doi: 10.4172/2157-7536.S12-e001
• Godwin, J.S.^#, C.F. Hodgman^#, A.R. Needle, K.A. Zwetsloot, and R.A. Shanely. Whole-body Heat Shock Accelerates Recovery from Impact-Induced Skeletal Muscle Damage in Mice. Conditioning Medicine. 2(4): 184-191. August 2020. http://www.conditionmed.org/Data/View/9543?type=300
• Nieman, D.C., K.A. Zwetsloot, A.J. Simonson, A.T. Hoyle, X. Wang, H.K. Nelson, C. Lefranc-Millot, and L. Guerin-Deremaux. Effects of Whey and Pea Protein Supplementation on Post-Eccentric Exercise Muscle Damage: A Randomized Trial. Nutrients. 12(8): 2382. August 2020. doi: 10.3390/nu12082382
• Lawrence, M.M.^#, K.A. Zwetsloot, S.T. Arthur, C.A. Sherman^#, J.R. Huot, V. Badmaev, M. Grace, M.A. Lila, D.C. Nieman, and R.A. Shanely. Phytoecdysteroids Do Not Have Anabolic Effects in Skeletal Muscle in Sedentary Aging Mice. International Journal of Environmental Research and Public Health - Special Issue: Regulation of Muscle Mass, Exercise, and Metabolism. 18, 370. January 2021.  doi: 10.3390/ijerph18020370
• Zwetsloot, K.A., R.A. Shanely, J.S. Godwin^#, and C.F. Hodgman^#. Phytoecdysteroids Accelerate Recovery of Skeletal Muscle Function Following in vivo Eccentric Contraction-Induced Injury in Adult and Old Mice. Frontiers in Rehabilitation Sciences - Exercise and Aging with Musculoskeletal Conditions. 2. 1-13. November 2021. doi: 10.3389/fresc.2021.757789
• Koopmans, P.J.^# and K.A. Zwetsloot. A simple and inexpensive running wheel model for progressive resistance training in mice. Journal of Visualized Experiments. (182), e63933, April 2022. doi:10.3791/63933
• Stewart, J.A.^#, E.K. Merritt, D.E. Lidstone, J.M. McBride, and K.A. Zwetsloot. Prolonged cycling lowers subsequent running mechanical efficiency in collegiate triathletes. BMC Sports Science, Medicine, and Rehabilitation. 14(149). August 2022. doi: 10.1186/s13102-022-00543-w
• Koopmans, P.J.^#, T.K. Williams-Frey^#, and K.A. Zwetsloot. "Stuart has got the PoWeR! Skeletal muscle adaptations to a novel heavy progressive weighted wheel running exercise model in C57BL/6 mice." Experimental Physiology. 109:271-282.October 2023. doi.org/10.1113/EP091494
• Koopmans, P.J.^#, K.A. Zwetsloot, and K.A. Murach. Invited Review: “Going Nuclear: Molecular adaptations to exercise mediated by myonuclei” - Special Issue: "Molecular Mechanisms of Exercise-Induced Skeletal Muscle Health”; Sports Medicine and Health Science. 5.1. March 2023. doi: 10.1016/j.smhs.2022.11.005
• Brooks, C.N., M.E. Wight^#, O.E. Azeez^#, R.M. Bleich, and K.A. Zwetsloot. Invited Review: “Growing old together: What we know about the influence of diet and exercise on the aging host’s microbiome.” Frontiers in Sports and Active Living. 5:1168731. April 2023. doi: 10.3389/fspor.2023.1168731

Education

• Ph.D. in Kinesiology (Biomechanics), The Pennsylvania State University, 2014

• M.S. in Kinesiology (Biomechanics), The Pennsylvania State University, 2008

• B.Soc.Sci. in Sports Psychology, The University of Pretoria (South Africa), 2004

• B.Eng. in Electrical Engineering, The University of Pretoria (South Africa), 1998

Current Teaching

• ES 3550 – Introduction to Biomechanics
• ES 5591 – Biomechanical Laboratory Assessment

Professional Affiliations / Organizations

• American Society of Biomechanics

Laboratory Affiliation

• Measuring Motion (Director)

Research Interests

• Novel motion analysis techniques to assess movement outside the traditional laboratory

Selected Publications

• Hawley, VS, Gurchiek, RD, van Werkhoven, H. (2022). Can foot anthropometry predict vertical jump performance? Journal of Strength and Conditioning Research, 36(7), 1860-1865.
• Farina, KA, Needle AR, van Werkhoven, H. (2021). Continuous tracking of foot strike pattern during a maximal 800-meter run. Sensors, 21(17), 5782.
• van Werkhoven, H, Farina, KA, Langley, MH. (2019). Using a soft conformable foot sensor to measure changes in foot strike angle during running. Sports, 7, 184.
• Gurchiek, RD, McGinnis, RS, Needle AR, McBride, JM, van Werkhoven, H. (2018). An adaptive filtering algorithm to estimate sprint velocity using a single inertial sensor. Sports Engineering, 21, 389-399.
• van Werkhoven, H, Piazza, SJ. (2017). Does foot anthropometry predict metabolic cost in running? Journal of Applied Biomechanics, 33, 317-322.
• Gurchiek, RD, McGinnis, RS, Needle AR, McBride, JM, van Werkhoven, H. (2017) The use of a single inertial sensor to estimate 3-dimensional ground reaction force during accelerative running tasks. Journal of Biomechanics, 61, 263-268.

Education

• Postdoctoral Fellowship - University of Missouri, Columbia
  July 2006

• Doctor of Philosophy - University of Florida, Gainesville, FL
  Emphasis: Exercise Physiology
  December 2002

• Master of Arts in Exercise Science - Northern Arizona University, Flagstaff, AZ
  Emphasis: Exercise Physiology
  December 1996

• Bachelor of Science in Physical Education - California State University Fullerton, Fullerton, CA
  January 1993

Teaching Specialties

• Exercise Physiology
• Muscle Biology
• Respiratory Physiology

Current Teaching

• ES 3002 Exercise Physiology
• ES 3003 Exercise Physiology Laboratory 
• ES 3005 Advanced Physiological Assessment
• ES 5622 Skeletal Muscle Physiology 

Professional Affiliations / Organizations

• American Physiological Society
• American College of Sports Medicine
• American College of Sports Medicine, Southeastern Chapter
• Public Responsibility in Medicine & Research

Laboratory Affiliation

• Integrative Muscle Physiology Lab
• Neuromuscular Laboratory

Research Interests

My research objective is to understand molecular and cellular regulation of skeletal muscle physiology and health across the life span.  

• Sarcopenia (the age related loss of skeletal muscle mass and function)
• Skeletal muscle atrophy
• Inactivity-induced oxidative stress 
• Exercise-induced muscle damage
• Skeletal muscle density and its relation to health 

Current Research Project

• Examining the relationship between skeletal muscle strength, power and intramuscular fat in healthy adults

Selected Publications 

Click to view my publications via Google Scholar

• Zwetsloot KA, Shanely RA, Godwin JS, Hodgman CF. Phytoecdysteroids Accelerate Recovery of Skeletal Muscle Function Following In Vivo Eccentric Contraction-Induced Injury in Adult and Old Mice.  Frontiers in Rehabilitation Sciences; 2:757789, doi: 10.3389/fresc.2021.757789; Special Issue: Exercise and Aging with Musculoskeletal Conditions
• Lawrence MM, Zwetsloot KA, Arthur ST, Sherman CA, Huot JR, Badmaev V, Grace M, Lila MA, Nieman DC, Shanely RA. Phytoecdysteroids do not have anabolic effects in skeletal muscle in sedentary aging mice. International Journal of Environmental Research and Public Health; 18, 370, 2021; Special Issue: Regulation of Muscle Mass, Exercise, Metabolism
• Godwin JS, Hodgman CF, Needle AR, Zwetsloot KA, Shanely RA. Whole-body Heat Shock Accelerates Recovery from Impact-Induced Skeletal Muscle Damage in Mice. Conditioning Medicine, 2(4): 184-191, 2020
• Shanely RA**, Zwetsloot JJ**, Jurrissen TJ, Carson LT, Needle AR, Zwetsloot KA, Bishop A, Wu G, Perkins-Veazie P. Expression of systemic markers of atherosclerosis in overweight, postmenopausal women following daily watermelon consumption for six weeks: A randomized controlled trial. **Authors contributed equally to this work. Nutrition Research, 76:9-19, 2020
• Shanely RA, Nieman DC, Perkins-Veazie P, Henson DA, Meaney MP, Knab AM, Cialdella-Kam L, Sha W. Comparison of Watermelon and Carbohydrate Beverage on Exercise-Induced Alterations in Systemic Inflammation, Immune Dysfunction, and Plasma Antioxidant Capacity. nutrients, 2016, 8(8), 518; Special Edition: Nutrition, Health and Athletic Performance
• Nieman DC, Shanely RA, Zwetsloot KA, Meaney MP, Farris GE. Ultrasonic assessment of exercise-induced change in skeletal muscle glycogen content. BMC Sports Science, Medicine, and Rehabilitation. 7:9, 2015
• Arthur ST, Zwetsloot KA, Lawrence MM, Nieman DC, Lila MA, Grace MH, Howden R, Cooley ID, Tkach JF, Keith MD, Demick JL, Blanton SE, Greiner RS, Bradley AM, Davenport ME, Badmaev VE, Shanely RA. Ajuga turkestanica increases Notch and Wnt signaling in aged skeletal muscle. Eur Rev Med Pharmacol Sci. 18:2584-92, 2014
• Shanely RA, Zwetsloot KA, Triplett NT, Meaney MP, Farris GE, Nieman DC. Human skeletal muscle biopsy procedures using the modified Bergström technique. J. Vis. Exp. 91, e51812, 2014
• Zwetsloot KA, Casey SJ, Battista RA, Shanely RA. High intensity interval training induces a modest systemic inflammatory response in active, young men. J Inflamm Res. 7:9-17, 2014
• Shanely RA, Nieman DC, Knab AM, Meaney MP, Jin F, Cialdella-Kam L, Gillitt ND. Influence of vitamin D mushroom powder on exercise-induced muscle damage in vitamin D insufficient high school athletes. J Sports Sci. 32:670-9, 2014
• Shanely RA, Nieman DC, Zwetsloot KA, Knab AM, Imagita H, Luo B, Davis B, Zubeldia JM. Evaluation of the effects of Rhodiola rosea supplementation in skeletal muscle damage and inflammation following a competitive marathon. Brain, Behavior, Immun. 39:204-10, 2014

Education

• Post-Doctoral Fellowship, 1999
  University of Jyvaskyla (Finland), Neuromuscular Research Center
  Major field of study: Biomechanics

• Ph.D., Southern Cross University (Australia), 1999
  School of Exercise Science and Sport Management
  Major field of study: Human Movement Studies

• M.S., The Pennsylvania State University, 1995
  Department of Exercise and Sport Science
  Major field of study: Exercise Physiology

• B.S., West Virginia University, 1993
  Department of Physical Education
  Major field of study: Exercise Physiology

Teaching Specialties

• Biomechanics

Current Teaching

• ES 3550 Introduction to Biomechanics
• ES 5591 Biomechanical & Physiological Laboratory Assessment
• ES 5710 Biomechanics

Professional Affiliations / Organizations

• National Strength & Conditioning Association

Laboratory Affiliation

• Neuromuscular and Biomechanics (Director)

Research Interests

• Muscle Strength & Power, Athletic Performance, Stretch-Shortening Cycle

Recent Publications

• McBride, J.M. Muscle actuators, not springs, drive maximal effort human locomotive performance. Journal of Sports Science and Medicine, Volume 20, Issue 4, 766-777, 2021.
• Mcbride, J.M., S. Nimphius. Biological system algorithm reflected in sub-system joint work distribution movement strategies: Influence of strength and eccentric loading, Scientific Reports, Volume 10, Issue 1, 12052, 2020.
• Maroto-Izquierdo, S., I. Gonzalez-Diez, D. Garcia-Lopez, J.M. Mcbride, J. Gonzalez-Gallego, J.A. Depaz. Comparison of flywheel and pneumatic training on hypertrophy, strength and power in professional handball players, Research Quarterly For Exercise And Sport, Volume 15, Pages 1-15, 2020.
• Gurchiek, R.D., H. Rupasinghe, L. Watagoda, R.S. Mcginnis, H. Van Werkhoven, A.R. Needle, J.M. Mcbride, A.T. Arnholt. Sprint assessment using machine learning and a wearable accelerometer. Journal Of Applied Biomechanics, Volume 24, Pages 1-16, 2019.

Education

• PhD - Growth and Motor Development - Michigan State University

• MS - Exercise Physiology - Indiana University

• BS - Physical Education Studies - University of Delaware

• BS - Health Science - Lock Haven University

Teaching Specialities

• ES 5200 Exercise Science Seminar
• ES 2030 Concepts in Anatomy and Physiology
• ES 2005 Introduction to Physiological Assessment
• ES 2020 Measurement and Evaluation
• ES 3005 Advanced Physiological Assessment
• ES 3590 Interprofessional Approaches to Health and Physical Activity
• ES 3700 Professional Development in Exercise Science
• ES 4050 Practicum: Pre-Professional
• ES 4100 Advanced Topics in Exercise Science

Professional Affiliations / Organizations

• American College of Sports Medicine
• North American Association of Pediatric Exercise Science
• Council on Undergraduate Research – Health Sciences

Laboratory Affiliation

• Healthy Outdoor Play and Exercise (HOPE)

Research Interests

• Physical activity and children and youth
• Improving motor development to increase physical activity in children 
• Youth sports
• Physical characteristics of college athletes across a competitive career

Selected Publications

Manuscripts

• Battista, R.A., West, S.T., Mackenzie, S.H., and Son J. (2016).  Is this exercise?  No, it’s geocaching! Exploring factors related to aspects of geocaching participation.  Journal of Park and Recreation Administration, 34(2), 30-48. DOI:http://dx.doi.org/10.18666/JPRA-2016-V34-I2-6495.  
• Battista, R.A.  (2015).  Physical literacy: Teaching children the ABC’s of movement.  ACSM Fit Society, 17(3), 1-2.
• McBride, J.M., Davis, J.A., Alley, J.R., Knorr, D.P., Goodman, C.L., Snyder, J,G., and Battista, R.A. (2015)  Index of mechanical efficiency in competitive and recreational long distance runners.  Journal of Sports Sciences. 33(13), 1388-1395 DOI: 10.1080/02640414.2014.990487
• Battista, R.A., Oakley, H., Weddell, M.S., Mudd, L.M., Greene, J.B., and West, S.T. (2014). Improving the physical activity and nutrition environment through self-assessment (NAP SACC) in rural area child care centers in North Carolina. Preventative Medicine, 67(1), S10-S16. DOI: 10.1016/j.ypmed.2014.01.022
• Zwetsloot, K.A., John, C.S., Lawrence, M.M., Battista, R.A., and Shanely, R.A. (2014). High-intensity interval training induces a modest systemic inflammatory response in active, young men. Journal of Inflammation Research, 7, 9-17.
• Battista, R.A., Foster, C., Davis, J. And Wright, G.  (2012).  The female athlete triad in physically active college aged females.  Gazzetta Medica Italiana, 171(1), 35-43.   
• Mally, K.K., Battista, R.A. and Roberton, M.A.  (2011).  Distance as a control parameter for place kicking. Journal of Human Sport and Exercise, 6(1), 122-134.
• Fencl, M., Muras, J., Steffen, J., Battista, R., and Elfessi, A.  (2011).  Physiological effects of bouldering activities in upper elementary school students.  The Physical Educator, 68(4), 199-209.
• Pettitt, R.W., Udermann, B.E., Wright, G., Battista, R.A., Mayer, J.M., and Murray, S.R. (2010).  Time-Course of DOMS Evoked by Three Intensities of Lumbar Eccentric Exercise.  Athletic Training & Sports Health Care, accepted for publication. 
• Murry, S.R., Udermann, B.E., Reineke, D.M., and Battista, R.A.  (2009).  Energy expenditure of sport stacking.  The Physical Educator, 180-185.
• Johnson, B.D., Joseph, T., Wright, G., Battista, R.A., Dodge, C., Balweg, A., deKoning, J.J., and Foster, C.  (2009).  Rapidity of responding to a hypoxic challenge during exercise.  European Journal of Applied Physiology, 106, 493-499.
• Foster, C., Hendrickson, K..J., Peyer, K, Reiner, B., deKoning, J.J., Lucia, A., Battista, R.A., Hettinga, F.J., Porcari, J.P., and Wright, G.  (2009).  Pattern of developing the performance template.  British Journal of Sports Medicine, 43, 765-769.
• Foster, C., Porcari, J.P., Battista, R. A., Udermann, B., Wright, G., and Lucia, A.  (2008).  The risk in exercise training.  American Journal of Lifestyle Medicine, 2, 279-284.   
• Battista, R.A., Foster, C., Andrew, J., Wright, G., Lucia, A., and Porcari, J.P.  (2008).  Physiological response during indoor cycling.  Journal of Strength and Conditioning Research, 22, 1236-1241.  
• Joseph, T., Johnson, B., Battista, R.A., Wright, G., Dodge, C., Porcari, J.P., deKoning, J., and Foster, C.  (2008).  Perception of fatigue during simulated competition.  Medicine and Science in Sports and Exercise, 40(2), 381-386.
• Foster, C., Kuffel, E., Bradley, N., Battista, R.A., Wright, G., Porcari, J.P., Lucia, A., and deKoning, J.  (2007).  VO2max during successive maximal efforts.  European Journal of Applied Physiology, 102, 67-72.  
• Foster, C., Wright, G., Battista, R.A., and Porcari, J.P.  (2007).  Training in the aging athlete.  Current Sports Medicine Reports, 6, 200-206.
• Battista, R.A., Pivarnik, J.M., Dummer, G.M., Sauer, N., and Malina, R.M.  (2007).  Comparisons of physical characteristics and performance among collegiate female rowers.  Journal of Sports Sciences, 25(6), 651-657.   
• Cumming, S.P., Battista, R.A., Standage, M, Ewing, M.E., and Malina, R.M.  (2006).  Estimated maturity status and perceptions of adult autonomy support in youth soccer players.  Journal of Sports Sciences, 24(10), 1039-1046.

Books

• Senior and Associate Editor, ACSM’s Resources for the Personal Trainer, 4th edition and 5th edition