Department of Public Health and Exercise Science

Education

• Post-doctoral research fellowship - University of Missouri, Columbia

• Ph.D. in Bioenergetics - East Carolina University

• M.A. in Physical Education - California State University, Chico

• B.S. in Exercise Physiology - California State University, Chico

Current Teaching

• ES 3002 – Exercise Physiology
• ES 3005 –Advanced Physiological Assessment
• ES 3700 – Professional Development in Exercise Science
• ES 5623 – Graduate Exercise Physiology

Professional Affiliations / Organizations

• American Physiological Society
• American College of Sports Medicine

Laboratory Affiliation

• Biochemistry (Director)
• Vivarium

Research Interests

• My research focuses on investigating the mechanisms responsible for sarcopenia (the age-related loss of skeletal muscle mass and strength) and developing exercise interventions for the treatment/prevention of sarcopenia.  Additionally, we are interested in mechanisms responsible for skeletal muscle recovery and regeneration after injury. More specifically, my laboratory investigates the role inflammation plays in muscle atrophy, as well as during recovery and regeneration after injury.

Current research projects include:

• Skeletal muscle repair after injury using a downhill running model in mice
• Natural plant steroid (phytoecdysteroids) supplementation during skeletal muscle repair from injury in mice - Collaboration with Dr. Andy Shanely
• Determination of exercise-induced skeletal muscle inflammation in young and old individuals using microdialysis - Collaboration with Dr. Ed Merritt
• Effect of Cycling on Mechanical Efficiency and Running Economy in Triathletes -Collaboration w/ Dr. McBride

Future projects:

• Determining whether exercise training improves oxidative function in skeletal muscle tissue in a pig model of heart failure with preserved ejection fraction (HFpEF) -Collaboration with Dr. Craig Emter (University of Missouri)
• Effect of Conjugated Linoleic Acid Supplementation on Muscle Mass and Strength in Elderly Men and Women – Collaboration with Dr. David Nieman (ASU-HumanPerformance Lab at the North Carolina Research Campus in Kannapolis, NC)

Selected Publications

Peer-Reviewed Research Papers

Nieman, D.C., K.A. Zwetsloot, M.P. Meaney, D.D. Lomiwes, S.M.Hurst, and R.D. Hurst.  “Post-Exercise Skeletal Muscle GlycogenRelated to Plasma Cytokines and Muscle IL-6 Protein Content, but notMuscle Cytokine mRNA Expression.” Frontiers in Nutrition. 2:27.2015. PubMed ID: 26442273

Goodman, A.*, K.A. Zwetsloot*, and A.R. Needle. “Effect ofBacrobial® skin cleanser on the prevention of muscle cramps.” Journalof Sports Science. 3. 219-222. 2015.  * - denotes authors contributedequally to this work.  doi:10.17265/2332-7839/2015.05.003

Nieman, D.C., R.A. Shanely, K.A. Zwetsloot, M.P. Meaney, and G.E.Farris.  “Ultrasonic assessment of exercise-induced change in skeletalmuscle glycogen content.” BMC Sports Science, Medicine, andRehabilitation. 7:9. 2015. doi:10.1186/s13102-015-0003-z

Arthur, S.T., K.A. Zwetsloot, M.M. Lawrence#, D.C. Nieman, M.A.Lila, R. Howden, I. Cooley, J. Tkach, M. Keith, J. Demick, S. Blanton,A. Gross, R. Greiner, A. Bradley, M. Davenport, V. Badmaev, andR.A. Shanely. “Ajuga turkestanica increases Notch and Wnt signalingin aged skeletal muscle.”  European Review for Medical andPharmacological Sciences. 18(17): 2584-92. 2014. # - denotesgraduate student co-author. PubMed ID: 25268108

Shanely, R.A., K.A. Zwetsloot, N.T. Triplett, M.P. Meaney, G.E.Farris, and D.C. Nieman. “Human skeletal muscle biopsy proceduresusing the modified Bergström technique.” Journal of VisualizedExperiments. (91) e51812. 2014.  doi:10.3791/51812

Zwetsloot, K.A., C.S. John#, M.M. Lawrence#, R.A. Battista, and R.A.Shanely. “High intensity interval training induces a modestinflammatory response in young active men.” Journal of InflammationResearch. 7. 9-17. 2014. # - denotes graduate student co-author. doi:10.2147/JIR.S54721.

Shanely, R.A., D.C. Nieman, K.A. Zwetsloot, A.M. Knab, H. Imagita,B. Lao, B. Davis, and J.M. Zubeldia. "Influence of Rhodiola roseasupplementation on skeletal muscle damage and inflammation inrunners following a competitive marathon". Brain, Behavior, andImmunity. 39: 204-10. 2014. doi: 10.1016/j.bbi.2013.09.005.

Goodman, A.* and K.A. Zwetsloot*. “Reliability of a protocol tovoluntarily induce muscle cramping.” International Journal of AthleticTherapy & Training. 18(6). 40-43. 2013. * - denotes authorscontributed equally to this work.

Zwetsloot, K.A., T.E. Childs, L.T. Gilpin, and F.W. Booth. “Zero-passaged muscle precursor cells from old skeletal muscle have delayed proliferation and differentiation.” Cell Proliferation. 46(1). 45-57. 2013. doi: 10.1111/cpr.12007.

Zwetsloot, K.A.*, A. Nedergaard*, T.E. Childs, and F.W. Booth.“Differences in transcriptional patterns of extracellular matrix,inflammatory, and myogenic regulatory genes in myofibroblasts,fibroblasts, and muscle precursor cells isolated from old male ratskeletal muscle using a novel cell isolation procedure.”Biogerontology. 13(4). 383-398. 2012. * - denotes authors contributedequally to this work. doi: 10.1007/s10522-012-9382-7.

Shanley, R.A.*, K.A. Zwetsloot*, T.E. Childs, S.J. Lees, and F.W.Booth. “IGF-I activates the mouse type IIb myosin heavy chain gene.”American Journal of Physiology – Cell Physiology. 297(4). C1019-1027. 2009. * - denotes authors contributed equally to this work. doi:10.1152/ajpcell.00169.2009.

Zwetsloot, K.A., L.M. Westerkamp, B.F. Holmes, and T. P. Gavin.“AMPK regulates basal skeletal muscle capillarization and VEGFexpression, but is not necessary for the angiogenic response toexercise.” Journal of Physiology. 586(24). 6021-6035. 2008. doi:10.1113/jphysiol.2008.159871.

Invited Reviews and Editorials

Zwetsloot, K.A., R.A. Shanely, E.K. Merritt, and J.M. McBride.Invited Review: “Phytoecdysteroids: A Novel, Non-AndrogenicAlternative for Muscle Health and Performance.”  Journal of Steroids& Hormonal Science. 12:e001. 2014. doi: 10.4172/2157-7536.S12-e001.

Booth, F.W. and K.A. Zwetsloot. “Basic concepts about Genes,Inactivity, and Aging.” Invited Review. Scandinavian Journal ofMedicine & Science in Sports. 20(1). 1-4. 2009. doi: 10.1111/j.1600-0838.2009.00972.x.

Zwetsloot, K.A., M.J. Laye, and F.W. Booth. Novel epigeneticregulation of skeletal muscle myosin heavy chain genes. Focus on“Differential epigenetic modifications of histones at the myosin heavychain genes in fast and slow skeletal muscle fibers and in response tomuscle unloading”. Editorial Focus. American Journal of Physiology –Cell Physiology. 296(7). C1-C3. 2009. doi:10.1152/ajpcell.00176.2009.